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Makarand V Risbud Selected Research

Intervertebral Disc Degeneration

6/2021Development of a standardized histopathology scoring system using machine learning algorithms for intervertebral disc degeneration in the mouse model-An ORS spine section initiative.
1/2021Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice.
1/2021Understanding embryonic development for cell-based therapies of intervertebral disc degeneration: Toward an effort to treat disc degeneration subphenotypes.
12/2020Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes.
1/2020Lactate Efflux From Intervertebral Disc Cells Is Required for Maintenance of Spine Health.
1/2019A New Understanding of the Role of IL-1 in Age-Related Intervertebral Disc Degeneration in a Murine Model.
12/2018Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration.
10/2018Glycosaminoglycan synthesis in the nucleus pulposus: Dysregulation and the pathogenesis of disc degeneration.
1/2017PHD3 is a transcriptional coactivator of HIF-1α in nucleus pulposus cells independent of the PKM2-JMJD5 axis.
3/2016TGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration.
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Makarand V Risbud Research Topics

Disease

29Hypoxia (Hypoxemia)
01/2021 - 06/2002
26Intervertebral Disc Degeneration
06/2021 - 11/2005
3Pain (Aches)
05/2019 - 01/2014
2Intervertebral Disc Displacement (Herniated Disc)
05/2020 - 10/2015
2Fibrosis (Cirrhosis)
05/2020 - 01/2019
2Inflammation (Inflammations)
10/2015 - 05/2013
1Bites and Stings (Sting)
01/2022
1Intervertebral disc disease
01/2020
1Neoplasms (Cancer)
01/2019
1Neck Pain (Cervicalgia)
10/2018
1Hypertrophy
01/2018
1Low Back Pain (Lumbago)
10/2015
1Scoliosis
11/2014
1Foreign-Body Reaction
10/2005
1Diabetes Mellitus
12/2002

Drug/Important Bio-Agent (IBA)

15CytokinesIBA
05/2020 - 11/2012
11Proteins (Proteins, Gene)FDA Link
03/2015 - 11/2005
4Transcription Factors (Transcription Factor)IBA
01/2021 - 08/2007
4Oxygen (Dioxygen)IBA
01/2021 - 08/2007
4Protein Isoforms (Isoforms)IBA
01/2018 - 06/2002
4Prolyl Hydroxylases (Prolyl Hydroxylase)IBA
01/2017 - 02/2012
4Messenger RNA (mRNA)IBA
07/2014 - 12/2007
3CollagenIBA
05/2020 - 01/2018
3Glucose (Dextrose)FDA LinkGeneric
01/2020 - 06/2002
3EnzymesIBA
10/2018 - 07/2011
3GlycosaminoglycansIBA
10/2018 - 07/2011
3Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2017 - 12/2008
3Galectin 3 (LGALS3)IBA
03/2016 - 12/2007
2Aggrecans (Aggrecan)IBA
05/2020 - 11/2011
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2020 - 02/2015
2Metalloproteases (Metalloproteinases)IBA
10/2018 - 11/2011
2Proteoglycans (Proteoglycan)IBA
10/2018 - 06/2014
2ChromatinIBA
01/2018 - 01/2018
2Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
11/2014 - 11/2004
2LuciferasesIBA
07/2014 - 05/2006
2IntegrinsIBA
03/2014 - 11/2005
2Deferoxamine (Desferal)FDA LinkGeneric
05/2006 - 04/2005
1Interferon Type IIBA
01/2022
1DNA (Deoxyribonucleic Acid)IBA
01/2022
1Bacterial DNAIBA
01/2022
1ORALIT (ORS)IBA
06/2021
1Drug CombinationsIBA
01/2021
1Dasatinib (BMS 354825)FDA Link
01/2021
1ThapsigarginIBA
01/2021
1SenotherapeuticsIBA
01/2021
1QuercetinIBA
01/2021
1TunicamycinIBA
01/2021
1Peptide Hydrolases (Proteases)FDA Link
05/2020
1Interleukin-6 (Interleukin 6)IBA
05/2020
1Fibronectins (Fibronectin)IBA
05/2020
1Biomarkers (Surrogate Marker)IBA
01/2020
1Lactic Acid (Lactate)FDA LinkGeneric
01/2020
1Tricarboxylic AcidsIBA
01/2020
1RNA-Binding Proteins (RNA-Binding Protein)IBA
01/2019
1Interleukin-1 (Interleukin 1)IBA
01/2019
1Carbonic Anhydrase IIIIBA
01/2018
1AntioxidantsIBA
01/2018
1Lactate Dehydrogenase 5IBA
01/2017
1theasinensin AIBA
01/2016
1Histone Deacetylase InhibitorsIBA
01/2016
1Toll-Like Receptors (Toll-Like Receptor)IBA
10/2015
1Anti-Bacterial Agents (Antibiotics)IBA
10/2015
1Aquaporin 1IBA
05/2015
1Aquaporins (Water Channels)IBA
05/2015
1angiogeninIBA
11/2014
1Dichlorodiphenyldichloroethane (DDD)IBA
11/2014
1Becaplermin (PDGF-BB)FDA Link
11/2014
1Heparitin Sulfate (Heparan Sulfate)IBA
06/2014
1Ion Channels (Ion Channel)IBA
01/2014
1CationsIBA
01/2014
1ADAMTS4 ProteinIBA
06/2013
1Connective Tissue Growth FactorIBA
05/2013
1HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA
05/2012
1Carrier Proteins (Binding Protein)IBA
05/2012
1ATP dependent 26S protease (26S proteasome)IBA
02/2012
1DisintegrinsIBA
11/2011
1ThrombospondinsIBA
11/2011
1LigandsIBA
05/2011
1diphosphoric acid (pyrophosphoric acid)IBA
09/2010
1Notch ReceptorsIBA
04/2010
1Integrin alpha2IBA
11/2005
1ChitosanIBA
10/2005
1Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA
04/2005
1Mitogen-Activated Protein KinasesIBA
04/2005
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
04/2005
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
04/2005
1Transforming Growth Factor beta (TGF-beta)IBA
12/2004
1HydrogelsIBA
12/2004
1EndoglinIBA
12/2004
1Transforming Growth Factor beta1 (TGF beta 1)IBA
12/2004
1Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA
12/2004
1Activated-Leukocyte Cell Adhesion Molecule (Neurolin)IBA
12/2004
1Hyaluronan ReceptorsIBA
12/2004
1AlginatesIBA
12/2004

Therapy/Procedure

6Therapeutics
06/2021 - 12/2002
1Punctures
05/2019
1Cell Transplantation
01/2015
1Diskectomy (Discectomy)
11/2014
1Biological Therapy
08/2013
1Aftercare (After-Treatment)
04/2005